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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19654 |
Guanoclor
胍氯酚,VATENSOL |
Others | Others |
Guanoclor (VATENSOL) 也称为guanochlor,是一种交感神经药物。已知它与猪肾膜中的非肾上腺素能位点结合。 | |||
T13383 |
Zamicastat
BIA 5-1058 |
BCRP; Hydroxylase; P-gp | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Zamicastat (BIA 5-1058) 是多巴胺 β-羟化酶 (DBH) 抑制剂,可透过血脑屏障引起中枢和周边效应,具有降血压作用。它也是一种浓度依赖性的双重 P-gp 和 BCRP 抑制剂,IC50值分别为 73.8 和 17.0 μM。 | |||
T6604 |
Nepicastat hydrochloride
Nepicastat HCl,内匹司他盐酸盐,RS-25560-197 hydrochloride,SYN-117 hydrochloride,Nepicastat (SYN-117) HCl |
Hydroxylase | Metabolism |
Nepicastat hydrochloride (RS-25560-197 hydrochloride) 是一种选择性的,有效的,口服活性的多巴胺 β 羟化酶(dopamine-beta-hydroxylase)抑制剂,对牛和人多巴胺 β 羟化酶的IC50分别为IC50=8.5 nM 和IC50=9 nM。Nepicastat HCl 可以穿过血脑屏障。 | |||
T61214 |
EWP 815
|
Phosphatase; Hydroxylase | Metabolism |
EWP 815 is a disulfiram analogue that functions as a powerful inhibitor of Ins(1,4) P 2 phosphatase, Ins(1,4,5) P 3 5-phosphatase, and dopamine β-hydroxylase activity [1] [2]. | |||
T11238L |
Etamicastat hydrochloride
BIA 5-453 hydrochloride |
Dehydrogenase | Metabolism |
Etamicastat hydrochloride (BIA 5-453 hydrochloride) 是一种外周选择性多巴胺β-羟化酶抑制剂,具有降低高血压的作用。 | |||
T50049 |
4-Methylhistamine hydrochloride
|
Others | Others |
4-Methylhistamine hydrochloride 已被证明能抑制铜依赖性酶如酪氨酸酶和多巴胺β-羟化酶的活性,还被证明可以调节参与细胞周期调节和凋亡的基因的表达。 | |||
T71942 |
3-Allylphenol
|
||
3-Allylphenol is an inhibitor of dopamine β-hydroxylase (DBH; Ki = 12 mM). | |||
T11238 |
Etamicastat
BIA 5-453 |
Dehydrogenase | Metabolism |
Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM. | |||
T60633 | Nepicastat | ||
Nepicastat (SYN117) 是一种选择性的,有效的,口服的多巴胺 β 羟化酶抑制剂,可穿过血脑屏障(BBB)。Nepicastat (SYN117) 对牛和人多巴胺 β 羟化酶产生浓度依赖性抑制作用,IC50值分别为8.5 nM 和 9 nM。 | |||
T36207 |
Methylspinazarin
|
||
Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-β-hydroxylase at 100 μg/ml. Methylspinazarin decreases blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg. |1. Chimura, H., Sawa, T., Takita, T., et al. Methylspinazarin and dihydromethylspinazarin, gate... | |||
T6356 |
(R)-Nepicastat HCl
RS-25560-198 HCl,盐酸内匹司他 |
Hydroxylase | Metabolism |
(R)-Nepicastat HCl (RS-25560-198 HCl) 是 Nepicastat HCl 的 R-对映异构体,是一种有效的选择性抑制剂,对牛和人多巴胺-β-羟化酶的 IC50 分别为 25.1 nM 和 18.3 nM,对其他 12 种酶和 13 种神经递质受体的亲和力可忽略不计. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6S0923 |
Hypericin
Hypericine,金丝桃素,Cyclosan |
Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Hypericin (Cyclosan) 是贯叶连翘的提取物,有抗菌、抗病毒、抗肿瘤和抗抑郁作用。 | |||
T10146 |
4-Hydroxyderricin
|
Dehydrogenase; MAO | Metabolism; Neuroscience |
4-Hydroxyderricin 是一种有效且具有选择性 MAO-B 抑制剂(IC50:3.43 μM),是当归的主要活性成分,能轻度抑制多巴胺β-羟化酶(DBH)活性,并具有抗抑郁活性。 |